JCI insightAnimalsEndoplasmic Reticulum Chaperone BiPMiceFibrosisTransforming Growth Factor beta1
Inhibition of cell surface GRP78 and activated α2M interaction attenuates kidney fibrosis.
Jackie Trink, Ifeanyi Kennedy Nmecha, Katrine Pilely, Renzhong Li, Zi Yang, Sydney Kwiecien, Melissa MacDonald, Bo Gao, Mariam A Mamai, Chao Lu, Urooj F Bajwa, Nikhil Uppal, James C Fredenburgh, Masao Kakoki, Salvatore V Pizzo
Published: 202510.1172/jci.insight.183998
Abstract
We recently showed that cell surface translocation of the endoplasmic reticulum-resident protein GRP78, when bound by activated α 2-macroglobulin (α2M*), induces pro-fibrotic responses in glomerular mesangial cells in response to high glucose and reg…
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