The Journal of clinical investigation
Rho/ROCK signaling and α-Catenin mediate β-Catenin-driven hyperplasia in the adrenal cortex via adherens junctions.
Mesut Berber, Betul Haykir, Nick A Guagliardo, Vasileios Chortis, Kleiton Silva Borges, Paula Q Barrett, Felix Beuschlein, Diana L Carlone, David T Breault
Published: 202610.1172/JCI196271
Abstract
How β-Catenin (βCat) mediates tissue hyperplasia is poorly understood. To explore this, we employed the adrenal cortex as a model system given its stereotypical spatial organization and the important role βCat plays in homeostasis and disease. For ex…
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