The Journal of clinical investigation
Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes.
Madison L Doolittle, Mitchell N Froemming, Jennifer L Rowsey, Ming Ruan, Leena Sapra, Joshua N Farr, David G Monroe, Sundeep Khosla
Published: 202610.1172/JCI195772
Abstract
Cellular senescence is a heterogeneous phenotype characterized primarily in mesenchymal cells, but the extent to which immune cells differ in their senescence phenotype, or "senotype", is unclear. Here, we applied single-cell approaches alongside bot…
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