The Journal of clinical investigation
Oncogenic KRAS/ERK/JUNB signaling suppresses differentiation regulator GATA6 in pancreatic cancer.
Zheng Zhong, Xinang Cao, Pei-Ju Liao, Raman Sethi, Jeffrey A Klomp, Clint A Stalnecker, Jinmiao Chen, Yue Wan, Channing J Der, David M Virshup
Published: 202510.1172/JCI191370
Abstract
GATA6 is a master regulator of differentiation in the pancreas and its expression levels determine the two main molecular subtypes of pancreatic cancer. High GATA6 contributes to the "classical" pancreatic cancer subtype, which is associated with a h…
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