The Journal of clinical investigation
ADAMTS7 promotes smooth muscle foam cell expansion in atherosclerosis.
Allen Chung, Lauren E Fries, Hyun-Kyung Chang, Huize Pan, Alexander C Bashore, Karissa Shuck, Caio V Matias, Juliana Gomez Pardo, Jordan S Kesner, Hanying Yan, Mingyao Li, Robert C Bauer
Published: 202610.1172/JCI187451
Abstract
Human genetic studies have repeatedly associated ADAMTS7 with atherosclerotic cardiovascular disease. Subsequent investigations in mice demonstrated that ADAMTS7 is proatherogenic and induced in response to vascular injury. However, the cell-specific…
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