The Journal of clinical investigation
MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling.
Fatmata Sesay, Hui Zhang, Priya Kapoor-Vazirani, Andrew T Jung, Mark E Essien, Amanda J Bastien, Nho C Luong, Xu Liu, PamelaSara E Head, Duc M Duong, Xiaofeng Yang, Zachary S Buchwald, Xingming Deng, Nicholas T Seyfried, David S Yu
Published: 202610.1172/JCI186711
Abstract
MRE11, a breast tumor suppressor and component of the MRE11-RAD50-NBS1 (MRN) complex, plays a critical role in DNA end resection and initiation of ATM-dependent DNA damage signaling. However, the precise mechanisms governing MRE11 function in the DNA…
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