American journal of respiratory cell and molecular biology
Macrophage CCL18 Promotes Lung Inflammation in Checkpoint Inhibitor Pneumonitis.
Mohammad I Ghanbar, Andres Villabona-Rueda, Nicolas Philip, Romy Rodriguez Ortega, Shannon Fonti, Arabellis Wally, Haiyang Jiang, Rulin Wang, Wilhelm Berger, Jeffrey Thiboutot, Hans Lee, Patrick Forde, Jarushka Naidoo, Julie Brahmer, Sang Taek Kim
Published: 202510.1165/rcmb.2025-0405OC
Abstract
Checkpoint inhibitor pneumonitis (CIP) is a highly morbid complication of immune checkpoint immunotherapy, characterized by acute lung injury leading, in severe cases, to hypoxic respiratory failure and death. CIP incidence in lung cancer is high (10…
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