American journal of respiratory and critical care medicine
Maternal Smoking and CC-16: Implications for Lung Development and COPD Across the Lifespan.
Joselyn Rojas-Quintero, Rosa Faner, Chia-Ying Chiu, Jeff T Kue, Yun Zhang, David Sanz Rubio, Adrianne S Colborg, Constanze A Jakwerth, Carsten B Schmidt-Weber, Anke-Hilse Maitland-van der Zee, Mahmoud I Abdel-Aziz, Aprile L Pilon, Caroline A Owen, Erin J Plosa, Gregory L Kinney
Published: 202510.1164/rccm.202504-0854OC
Abstract
RATIONALE: Early-life lung function trajectories predict long-term respiratory health, including COPD risk. Club Cell protein 16 (CC16) is a key determinant of lung health, with low levels associated with impaired lung development, reduced lung funct…
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