Journal of the American Heart AssociationHumansRheumatic Heart DiseaseMitral ValveFibrosisDisease Progression
Chronic Mitral Valve Fibrosis in Rheumatic Heart Disease: From Immune Trigger to Inflammatory and Mechanical Progression.
Zhou Liu, Ruifei Liu, Jiajun Liang, Maozhou Wang, Meili Wang, Hongjia Zhang, Wenjian Jiang
Published: 202510.1161/JAHA.125.045169
Abstract
Rheumatic heart disease is a chronic valvular disorder resulting from acute rheumatic fever, predominantly affecting the mitral valve and characterized by progressive fibrotic thickening. Although the initial insult is driven by autoimmune responses…
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