Journal of the American Heart AssociationAnimalsPhosphofructokinase-2MiceKnockoutMitochondria
PFKFB2 Is Pivotal for Metabolic Flexibility and Differential Glucose Utilization.
Kylene M Harold, Satoshi Matsuzaki, Atul Pranay, Jie Zhu, Anna Faakye, Kenneth M Humphries
Published: 202510.1161/JAHA.125.043921
Abstract
BACKGROUND: The heart's constant energy demands make metabolic flexibility critical to its function as nutrient availability varies. The enzyme phosphofructokinase-2/fructose 2,6-bisphosphatase (PFKFB2) contributes to this flexibility by acting as a…
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