Journal of the American Heart AssociationAnimalsSarcoplasmic Reticulum Calcium-Transporting ATPasesObesityEnergy MetabolismMice
Sarco/Endoplasmic Reticulum Ca2+ ATPase Activation Shifts Cardiac Fuel Preference Without Impairing Cardiac Function in Obese Mice.
Deveena R Banerjee, Clinton M Hasenour, Mohsin Rahim, Tomasz K Bednarski, Amanda C Doran, David A Jacobson, Jamey D Young
Published: 202610.1161/JAHA.125.042505
Abstract
BACKGROUND: Activity of SERCA (sarco/endoplasmic reticulum Ca2+ ATPase) affects cardiac metabolism and function and is under investigation in clinical trials. SERCA function also regulates glucose metabolism in multiple tissues, but it is unknown how…
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