Hypertension (Dallas, Tex. : 1979)AnimalsHypertensionAngiotensin IIMiceKnockout
Smooth Muscle LRRC8A Knockout Preserves Vascular Function in Ang II Hypertension.
Hyehun Choi, Sourav Panja, Hong-Ngan Nguyen, Ryan J Stark, Fred S Lamb
Published: 202610.1161/HYPERTENSIONAHA.125.25222
Abstract
BACKGROUND: Ang II (angiotensin II) causes hypertension and vascular inflammation both directly and indirectly via cytokines, including TNFα (tumor necrosis factor-α). In vascular smooth muscle cells (VSMCs), Ang II and TNFα activate Nox1 (NADPH oxid…
Preview only. Read the full abstract at the source