CirculationAldehyde DehydrogenaseMitochondrialFerroptosisAnimalsHumans
ALDH2/eIF3E Interaction Modulates Protein Translation Critical for Cardiomyocyte Ferroptosis in Acute Myocardial Ischemia Injury.
Xin Chen, Xiujian Yu, Shanshan Zhong, Ping Sha, Rui Li, Xiaodong Xu, Ningning Liang, Lili Zhang, Luxiao Li, Jingyu Zhang, Mingyao Zhou, Tongwei Lv, Haoran Ma, Yongqiang Wang, Yanwen Ye
Published: 202610.1161/CIRCULATIONAHA.125.075220
Abstract
BACKGROUND: As an iron-dependent form of regulated cell death caused by lipid peroxidation, ferroptosis has been implicated in ischemic injury, but the underlying mechanisms in acute myocardial infarction (AMI) remain poorly defined. ALDH2 (acetaldeh…
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