Circulation. Heart failure
Connexin-43 Restoration Alleviates Desmosomal Arrhythmogenic Cardiomyopathy.
Jing Zhang, Fabian Zanella, Matthew W Ellis, William H Bradford, Erika Joana Gutierrez-Lara, Tsui-Min Wang, Kyohei Fujita, Charlize Duron, Ioannis Karakikes, Robert C Lyon, Valeria Mezzano, Jason D Roberts, Cassiano Carromeu, Yusu Gu, Jody L Martin
Published: 202610.1161/CIRCHEARTFAILURE.125.013801
Abstract
BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is a fatal genetic heart disease primarily caused by mutations in desmosomal genes, leading to impaired cell-cell adhesion, ventricular arrhythmias, and progressive heart failure. Although gene therapy…
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