Circulation. Heart failure
Dephospho-Uncarboxylated Matrix Gla-Protein Is Associated With Adverse Outcomes in Heart Failure.
Mahesh K Vidula, Leon J Schurgers, Lei Zhao, Marie-Joe Dib, Manyun Zhao, Zhaoqing Wang, Christina Ebert, Oday Salman, Joe D Azzo, Payman Zamani, Vanessa van Empel, A Mark Richards, Rob Doughty, Ali Javaheri, Douglas L Mann
Published: 202610.1161/CIRCHEARTFAILURE.124.012734
Abstract
BACKGROUND: MGP (matrix Gla-protein), a known inhibitor of vascular calcification, becomes biologically active by vitamin K-dependent carboxylation. Circulating levels of dpucMGP (dephospho-uncarboxylated matrix Gla-protein), the inactive form of MGP…
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