Arteriosclerosis, thrombosis, and vascular biologyAnimalsFerroptosisAortic AneurysmAbdominalMice
Pharmacological Inhibition of Ferroptosis Attenuates Experimental Abdominal Aortic Aneurysm Formation.
Jonathan R Krebs, Paolo Bellotti, Walker Ueland, Jeff Arni C Valisno, Denny Joseph Manual Kollareth, Shiven Sharma, Gang Su, Joseph B Hartman, Aravinthan Adithan, Michael Spinosa, Manasi Kamat, Timothy Garrett, Guoshuai Cai, Ashish K Sharma, Gilbert R Upchurch
Published: 202510.1161/ATVBAHA.125.323269
Abstract
BACKGROUND: The pathogenesis of abdominal aortic aneurysm (AAA) formation involves vascular inflammation, thrombosis formation, and programmed cell death, leading to aortic remodeling. In this study, we deciphered the role of ferroptosis, an excessiv…
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