Arteriosclerosis, thrombosis, and vascular biologyAnimalsMarfan SyndromeBenzimidazolesBiphenyl CompoundsAngiotensin II Type 1 Receptor Blockers
Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Progressive Aortic Dilatation in Marfan Syndrome.
Hiroki Yagi, Hiroshi Akazawa, Qing Liu, Sayo M Ito, Masahiko Umei, Hiroshi Kadowaki, Ryo Matsuoka, Akito Shindo, Shun Okamura, Tomomi Ueda, Akiko Saga-Kamo, Kazutaka Ueda, Norifumi Takeda, Tappei Takada, Issei Komuro
Published: 202610.1161/ATVBAHA.125.322646
Abstract
BACKGROUND: Marfan syndrome is an inherited disorder caused by FBN1 gene mutations, which can lead to thoracic aortic aneurysm and dissection. Selective AT1 (angiotensin II type 1) receptor blockade is a preventive option against Marfan syndrome aort…
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