An Unusual Localized Reaction of Conjunctivitis with Systemic Use of Ketoprofen: A Case Report.

Introduction: Although the eye is rarely the sole target of an immediate allergic-type response, ocular signs and symptoms often represent the most prominent features of systemic allergic reactions. Nonsteroidal anti-inflammatory drugs (NSAIDs), due to their cyclooxygenase inhibitory activity, can trigger nonallergic hypersensitivity responses. Ketoprofen, in particular, is one of the most potent cyclooxygenase inhibitors at therapeutic plasma concentrations and is recognized as a frequent photoallergic agent. However, localized hypersensitivity reactions following systemic administration are exceedingly rare. This report describes an unusual case of allergic conjunctivitis occurring after oral administration of ketoprofen. Case Presentation: A 13-year-old Caucasian girl presented to the pediatric emergency department of a private hospital with swelling, progressive ocular redness, burning, itching, and upper airway obstruction. These symptoms developed shortly after the oral administration of ketoprofen (20 mg/mL), prescribed to manage a low-grade fever (37.9°C) and sore throat. No additional systemic manifestations were observed. Conclusion: An uncommon case of conjunctivitis following oral ketoprofen use highlights the need for further research on NSAID-induced hypersensitivity and the value of detailed laboratory evaluation to clarify its causes.