EndoCompass Project: Research Roadmap for Endocrine Causes and Consequences of Cancers.
Jason S Carroll, Frederic Castinetti, Cecilia Follin, Raul M Luque, Annemarie A Verrijn Stuart, Aleksander Giwercman, Simona Grozinsky-Glasberg, Csilla Krausz, Stavroula A Paschou, Robin Peeters, Carolina R C Pieterman, Pauline Romanet, Juan M Jiménez-Vacas, Hanneke M van Santen, Karin Zibar Tomšic
Abstract
Open AccessBACKGROUND: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At the national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology - aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. RESULTS: Research priorities encompass re-evaluation of progestins in breast cancer treatment; strategies to disrupt AR signalling in prostate cancer; surveillance for endocrine sequelae in childhood cancer survivors; understanding genotoxic effects on fertility; and management of checkpoint inhibitor endocrinopathies and familial cancer syndromes. Emphasis is placed on precision medicine and metabolic factors in cancer. CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into cancer-endocrine pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact on endocrine health.