Blood cancer discoveryHumansLeukemiaLymphocyticChronicB-Cell
Overcoming BTK Inhibitor Resistance in Chronic Lymphocytic Leukemia by Targeting PKCβ.
Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer
Published: 202610.1158/2643-3230.BCD-25-0390
Abstract
Resistance of chronic lymphocytic leukemia to BTK inhibitors poses a major clinical challenge; however, there is potential to overcome this obstacle by targeting the downstream protein kinase PKCβ using the novel inhibitor MS-553. By inhibiting PKCβ,…
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