Cancer immunology researchHumansReceptorsChimeric AntigenNeoplasmsImmunotherapy
CAR-ving a Path: Metalloprotease-Engineered CAR T Cells Tunnel through Solid Tumors.
Alessandro Gasparetto, Roberto Chiarle
Published: 202510.1158/2326-6066.CIR-25-1097
Abstract
Overcoming the physical barriers of the tumor microenvironment remains a major obstacle for chimeric antigen receptor (CAR) T-cell therapy in solid tumors. In this issue, Van Pelt and colleagues show that engineering GD2-targeting CAR T cells to expr…
Preview only. Read the full abstract at the source