Cancer immunology researchHumansColorectal NeoplasmsCD8-Positive T-LymphocytesHeterogeneous-Nuclear Ribonucleoprotein Group A-BMice
HNRNPA2B1 Orchestrates Immune Evasion in Colorectal Cancer by Rewiring Tumor-Immune Cell Interactions and Suppressing CD8+ T-cell Infiltration.
Chuwei Liu, Heng Liang, Peipei Wang, Min Xiao, Yuyan Zheng, Shijia Yan, Yuan Deng, Ruonian Liu, Arabella H Wan, Zhi Wang, Xiongbin Lu, Wu Song, Weiling He, Guohui Wan
Published: 202610.1158/2326-6066.CIR-25-0433
Abstract
Immune checkpoint blockade (ICB) has transformed colorectal cancer therapy, yet the majority of microsatellite-stable colorectal cancers remain refractory because of insufficient tumor-immune cell cross-talk. Identifying molecular regulators that mod…
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