Cancer immunology research
Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFN-γ-ΙRF1-SREBF2 Axis.
Liping Xu, Xiaomin Zhang, Xiaowei Lai, Hongyuan Chen, Shuangye Liao, Mingzeng Chang, Xiaoqing Wu, Wen Rui, Juan Yang, Danyang Wang, Chengqi Gao, Ziqian Fang, Jianeng Zhang, Wende Li, Bo Li
Published: 202510.1158/2326-6066.CIR-25-0242
Abstract
Tumor cells employ metabolic mechanisms to limit antitumor immunity and promote resistance to immunotherapy. However, how immunotherapy modulates tumor metabolism remains unclear. Here, we demonstrated that anti-PD-1 treatment regulated cholesterol b…
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