Cancer immunology research
A universal boosting strategy for adoptive T cell therapy using a paired vaccine/chimeric antigen receptor.
Rebecca Burchett, Claire G Morris, Mira Ishak, Nickolas J Serniuck, Derek T Cummings, Christopher L Baker, Ricardo Marius, Natasha Kazdhan, Christopher M Silvestri, John Bell, Brian D Lichty, Scott R Walsh, Yonghong Wan, Joanne A Hammill, Jonathan L Bramson
Published: 202510.1158/2326-6066.CIR-25-0070
Abstract
Vaccines that encode tumour-associated antigens are potent boosting agents for adoptively transferred tumour-specific T cells. Employing vaccines to boost adoptively transferred tumour-reactive T cells relies on a priori knowledge of tumour epitopes,…
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