Cancer discovery
Epigenetic and transcriptional programs define osteosarcoma subtypes and establish targetable vulnerabilities.
Eunice Lopez-Fuentes, Andrew S Clugston, Alex G Lee, Leanne C Sayles, Natalie Sorensen, María V Pons Ventura, Stanley G Leung, Truc Dinh, Marcus R Breese, E Alejandro Sweet-Cordero
Published: 202510.1158/2159-8290.CD-25-0237
Abstract
Osteosarcoma is a genomically complex tumor characterized by widespread structural rearrangements. This complexity has limited development of therapeutic strategies informed by molecular mechanisms of oncogenesis. We hypothesized that epigenetic mech…
Preview only. Read the full abstract at the source