Cancer discovery
Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression.
Daniel D Azorín, Dirk C Hoffmann, Nils R Hebach, Erik Jung, David Hausmann, Miriam Ratliff, Ling Hai, Sandra Horschitz, Ammar Jabali, Matthias Osswald, Matthia A Karreman, Tobias Kessler, Susann Wendler, Chanté D Mayer, Cathrin Löb
Published: 202510.1158/2159-8290.CD-24-0414
Abstract
Glioblastomas are incurable primary brain tumors that depend on neural-like cellular processes, tumor microtubes (TMs), to invade the brain. TMs also interconnect single tumor cells to a communicating multicellular network that resists current therap…
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