Pattern-based p53 and p16 immunohistochemistry as a potential alternative to loss of heterozygosity testing for progression risk of oral epithelial dysplasia.

Oral epithelial dysplasia (OED) is the precursor to oral squamous cell carcinoma (OSCC), but histologic grading alone lacks reproducibility and prognostic power. This study evaluates whether pattern-based p53 and p16 immunohistochemistry (IHC) can se…

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