Molecular cancer research : MCR
Targeting LAMP2A enhances SELENBP1 expression and suppresses malignant behaviors in HNSCC.
Hongwei Cao, Dongsheng Xing, Hanbing Yu, Feifei Jiang, Li Qi, Kunrong Wang, Yan Wang, Aihui Yan
Published: 202510.1158/1541-7786.MCR-25-0388
Abstract
Lysosome-Associated Membrane Protein Type 2A (LAMP2A) serves as the critical rate-limiting component of chaperone-mediated autophagy (CMA), governing substrate translocation into lysosomes. Accumulating studies indicate that LAMP2A downregulation lea…
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