Molecular cancer therapeutics
NN-01-195, a novel conjugate of HSP90 and AURKA inhibitors, effectively targets solid tumors.
Theodore T Nguyen, Nitesh K Nandwana, Yellamelli V V Srikanth, Tetyana Bagnyukova, Oleksandra Chkalo, Kathy Q Cai, Julia Lamperelli, Shabnam Pirestani, Manish Kumar Mehra, Barbara A Burtness, Hossein Borghaei, Ravikumar Akunuri, Joel Cassel, Lily Lu, Joseph M Salvino
Published: 202610.1158/1535-7163.MCT-25-0857
Abstract
Aurora kinase A (AURKA) regulates cell cycle progression into and through mitosis. As overexpression of AURKA in cancer cells is common and associated with mitotic defects and aneuploidy, small molecule inhibitors of AURKA have been developed as cand…
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