Molecular cancer therapeutics
Enhanced Rho GTPase pathway activity promotes acquisition of glioblastoma chemoresistance.
Yuli T Magalhaes, Viktor K Boell, Fabio L Forti
Published: 202510.1158/1535-7163.MCT-25-0039
Abstract
Glioblastoma (GBM) is a highly aggressive tumor primarily treated through surgery, radiotherapy, and chemotherapy. GBM radioresistance involves the activation of the Rho GTPase pathway, actin cytoskeleton polymerization, and the cytoplasmic retention…
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