Molecular cancer therapeutics
Vitamin C conditioning generates tumor-targeting CAR T cells with superior cytotoxicity and fitness in a post-transplant lymphoproliferative disorder tumor model.
Pegah Rahmati, Agnes Bonifacius, Anna Christina Dragon, Chiara Malinconico, Friederike Floegel, Anne Halenius, Rainer Blasczyk, Britta Maecker-Kolhoff, Michael Hudecek, Stefan Floess, Jochen Huehn, Britta Eiz-Vesper
Published: 202510.1158/1535-7163.MCT-25-0005
Abstract
CAR T-cell therapy has shown efficacy in hematological malignancies but faces challenges in solid tumors and virus-associated malignancies such as post-transplant lymphoproliferative disorder (PTLD). Various strategies, including optimization of rece…
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