Clinical cancer research : an official journal of the American Association for Cancer Research
A Phase 2 Trial of an Extended-release siRNA Implant Targeting KRAS G12D/V in Locally Advanced Pancreatic Cancer.
Brinda Alagesan, Anna M Varghese, Celina Ang, Martin Gutierrez, Moshe Kamar, Maria Passhak, Ravit Geva, Nirit Yarom, Maor Lahav, Rosario Ligresti, Iyad Khamaysi, Manoop S Bhutani, Adam Phillips, Shay Matalon, Orit Pollack-Shragai
Published: 202610.1158/1078-0432.CCR-25-3189
Abstract
PURPOSE: Locally advanced pancreatic cancer (LAPC) accounts for 30% of pancreatic cancers. We assessed the efficacy and safety of a novel extended-release siRNA targeting KRAS G12D/V mutations (siG12D-LODER) combined with chemotherapy in LAPC. PATIEN…
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