Clinical cancer research : an official journal of the American Association for Cancer ResearchHumansProto-Oncogene Proteins c-aktProtein Kinase InhibitorsBreast NeoplasmsMutation
Tumor-Agnostic AKT Inhibition: Is It Time to AKT?
Ricardo Dahmer Tiecher, Alison M Schram
Published: 202510.1158/1078-0432.CCR-25-2640
Abstract
Basket trials of AKT-mutated tumors show that pan-AKT inhibitors are active in hormone receptor-positive breast cancer. There is mounting evidence for AKT inhibition in other tumor types, although small sample sizes limit evaluation of the tumor-agno…
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