Clinical cancer research : an official journal of the American Association for Cancer ResearchHumansNivolumabAntibodiesMonoclonalHumanized
Checkpoint Blockade Combinations in Tumor Mutational Burden/Load-High Tumors: Insights from the Atezolizumab + Bevacizumab and Nivolumab + Ipilimumab Cohorts in the Drug Rediscovery Protocol.
Karlijn Verkerk, Soemeya F Haj Mohammad, Laurien J Zeverijn, Birgit S Geurts, Ilse A C Spiekman, Florentine A J Verbeek, Hans Timmer, Maud A van Maren, V van der Noort, Miguel Parra-Martinez, Paul Roepman, Anne M L Jansen, Wendy W J de Leng, Serena Marchetti, Kim Monkhorst
Published: 202510.1158/1078-0432.CCR-25-2260
Abstract
PURPOSE: To evaluate the efficacy of atezolizumab plus bevacizumab (atezo + beva) in tumors with high tumor mutational burden (TMB; number of mutations per megabase) and nivolumab plus ipilimumab (nivo + ipi) in tumors with high TMB or tumor mutation…
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