Clinical cancer research : an official journal of the American Association for Cancer ResearchHumansTumor Suppressor Protein p53NeoplasmsTumor MicroenvironmentMutation
p53: An Immune Ecosystem Manipulator.
Zhigang Nian, Yingchao Dou, Haiming Wei
Published: 202510.1158/1078-0432.CCR-24-3628
Abstract
Mutations in p53 are among the most common genetic abnormalities in cancer, and the loss of its normal function is a critical factor in cancer progression. In addition to autonomously inhibiting tumorigenesis, p53 mutations reshape the tumor immune m…
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