Cancer researchReactive Oxygen SpeciesHumansTelomereDNA DamageCD8-Positive T-Lymphocytes
Between ROS and a Hard Place: Telomere Damage as a Driver of T-cell Exhaustion.
Tanmana Mitra, Santosha A Vardhana
Published: 202610.1158/0008-5472.CAN-25-4716
Abstract
In recent years, the accumulation of mitochondrial reactive oxygen species (ROS) has been shown to limit the proliferative capacity and intratumoral persistence of CD8+ T cells, but the molecular mechanisms by which ROS produces functional defects in…
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