Cancer research
LINE-1 Retrotransposon Protein ORF1p Forms Condensates that Drive cGAS-Induced Immune Evasion in Lung Squamous Cell Carcinoma.
Biyuan Xing, Jialing Liu, Yongjie Xie, Pengpeng Liu, Lianmin Zhang, Wenjing Tian, Wenwen Yu, Hailong Wang, Jing Wang, Zeguo Sun, Weijia Zhang, Rui Zhang, Jinpu Yu
Published: 202610.1158/0008-5472.CAN-25-2611
Abstract
Lung squamous cell carcinoma (LUSC) is a lethal malignancy with limited treatment options, driven by an immunosuppressive tumor microenvironment (TME) and a paucity of actionable targets. Pathogenic LINE-1 (pL1HS) retrotransposons promote LUSC progre…
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