Cancer research
KLF5 Activation Promotes Malignant Transformation to Drive Development of Lung Squamous Cell Carcinoma.
Junwei Zeng, Qing Li, Jiaqi Zhang, Zhe Yu, Ning Jiang, Xinghua Cheng, Yin Li, Xinhua Lin, Xiaofang Tang
Published: 202610.1158/0008-5472.CAN-25-2139
Abstract
Tumorigenesis is a multistep process requiring alterations in various gene expression programs. The transcription factor KLF5 is frequently genomically amplified and activated in multiple epithelial cancers, highlighting the need to define its role i…
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