Cancer research
MTAP Deletion in Oncogenesis: A Synthetic Lethality Scenario.
Jordi Rodon, Melissa L Johnson, Ben George, Pooja A Shah, Kathryn C Arbour
Published: 202610.1158/0008-5472.CAN-25-2126
Abstract
Homozygous deletions in the gene encoding methylthioadenosine phosphorylase (MTAP) occur in ~10% of patients with cancer, including up to 45% in some tumor types, and may be associated with poor prognosis. MTAP deficiency causes accumulation of its c…
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