Cancer research
CDK12 Deficiency Induces BRD4S to Promote Cancer Metastasis by Enhancing Phase Separation and Chromatin Engagement.
Hao Li, Jindan Luo, Huaiyuan Liang, Yanfeng Bai, Jiandong Liu, Ting Wei, Liguo Wang, Hongshan Guo, Dan Xia, Haojie Huang, Rui Sun
Published: 202510.1158/0008-5472.CAN-25-1761
Abstract
CDK12 is frequently deleted and/or mutated in human cancers, and CDK12 inactivation is associated with aggressive phenotypes including the tendency to metastasis. Here, we showed that CDK12 deficiency induced intronic polyadenylation (IPA) usage in B…
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