Cancer research
Transfer of Damaged Mitochondria from Cancer Cells to Cancer-Associated Fibroblasts Promotes Tyrosine Kinase Inhibitor Tolerance in EGFR-Mutant Lung Cancer.
Tongyan Liu, Shiyi Huang, Zhitong Li, Jianyu Li, Qinhong Sun, Qinglin Wang, Ziyang Shen, Zhijun Xia, Fanchen Meng, Youtao Xu, Wenjia Xia, Jing Tan, Rong Yin
Published: 202510.1158/0008-5472.CAN-25-0433
Abstract
Drug-tolerant persister (DTP) cells drive therapeutic resistance in EGFR-mutant lung adenocarcinoma. Using single-cell RNA sequencing, we identified a clinically significant RGS5+MYL9+ cancer-associated fibroblast (CAF) population that was associated…
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