Cancer research
PRDM16 Regulates Prostate Cancer Cell Dormancy and Prevents Bone Metastatic Outgrowth.
Mostafa M Nasr, Bishoy Wadie, Tao Li, Jeremy S Frieling, Haley du Bois, Ryan T Bishop, Marilena Tauro, Baasil Malik, Karl J Nyman, Conor C Lynch
Published: 202510.1158/0008-5472.CAN-24-4809
Abstract
Understanding dormancy in prostate cancer (PCa) is challenging due to model availability. Here, using murine and human PCa cell lines, we generated a stress-induced model of dormancy in vitro and demonstrated that the phenotype could be sustained upo…
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