Cancer research
Estrogen Production in Pancreatic Cancer Shapes a Tumor Suppressive Stromal Microenvironment.
Paul Manoukian, Deni M van Schie, Anne-Sophie van Schelt, Nienke P M Wassenaar, Mark P G Dings, Marjolein F Lansbergen, Cynthia Waasdorp, Rodrigo Leite de Oliveira, Wjera V Wickenhagen, Annemieke C Heijboer, Jan Koster, Danny A Zwijnenburg, Arantza Farina-Sarasqueta, Geert Kazemier, Johanna W Wilmink
Published: 202510.1158/0008-5472.CAN-24-4707
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death due to a lack of effective therapeutic interventions. PDAC tumors are highly fibrotic, and stromal abundance is hypothesized to contribute to patient outcomes. However…
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