Cancer research
Dynamic and Ongoing De Novo L1 Retrotransposition Contributes to Genome Plasticity and Intrapatient Heterogeneity in Ovarian Cancer.
Barun Pradhan, Jaana Oikkonen, Kaiyang Zhang, Juan Manuel Botto, Minna R Eriksson, Srividhya Sundaresan, Fatih Genç, Thomas R Pisanic, Matias Marin Falco, Yilin Li, Sanna Pikkusaari, Kari Lavikka, Giulia Micoli, Giovanni Marchi, Taru A Muranen
Published: 202510.1158/0008-5472.CAN-24-4419
Abstract
L1 retrotransposons are the only protein-coding active transposable elements in the human genome. While typically silenced in normal cells, they are highly expressed in many human epithelial cancers, including high-grade serous ovarian cancer (HGSC),…
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