Cancer researchHumansCarcinomaIntraductalNoninfiltratingBreast Neoplasms
Spatially Discontinuous Mutation Topographies in Ductal Carcinoma In Situ Reveal Noncompetitive Growth Dynamics.
Marc D Ryser, Matthew A Greenwald, Daniel Monyak, Inmaculada C Sorribes, Lorraine King, Allison Hall, Joseph Geradts, Donald L Weaver, Diego Mallo, Shannon T Holloway, Ethan Wu, Kevin A Murgas, Robert B West, Lars J Grimm, Carlo C Maley
Published: 202510.1158/0008-5472.CAN-24-4415
Abstract
Preinvasive breast cancer, or ductal carcinoma in situ (DCIS), shares many morphologic and genomic features with invasive breast cancer, yet most DCIS tumors remain indolent over decades. In this study, we performed spatial analyses of somatic mutati…
Preview only. Read the full abstract at the source