Cancer research
ETC-501 is a Brain Penetrant MNK Kinase Inhibitor that Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy.
Giselle Sek Suan Nah, Yuk Kien Chong, Fatin Nasha Sulaimi, Kian Leong Lee, See Wee Lim, Qing You Pang, Mengge Yu, Zhen Wei Neo, Jabed Iqbal, Kassoum Nacro, Jeffrey Hill, Alex Matter, Henry Yang, Beng Ti Ang, Carol Tang
Published: 202610.1158/0008-5472.CAN-24-4388
Abstract
Glioblastoma (GBM) is the deadliest primary brain tumor in adults, with a median survival of only 15 months and fewer than 10% of patients surviving beyond 5 years. Despite aggressive multimodal therapies, including surgical resection, radiation, and…
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