Impact of Molar Incisor Hypomineralization on Oral Health-Related Quality of Life in Teenagers and Parental Perception: A Meta-Analysis.

Background: The aim of this study was to assess the impact of molar incisor hypomineralization (MIH) on oral health-related quality of life (OHRQoL) in 11-14 years old children and parents/caregivers' perception. Materials and Methods: Articles published up to December 2023 were searched in Scopus, Web of Science, and PubMed databases. From 127 articles found initially, 20 studies were considered. Finally, 11 articles were eligible to be included, of which nine articles entered to meta-analysis. Six studies using the Child Perceptions Questionnaire (CPQ) 11-14 and three studies using the Parental-Caregiver's Perceptions Questionnaire (P-CPQ) contributed to meta-analyses. Results: In MIH affected children, the total score of CPQ 11-14 with the pooled mean of 13.56 (95% confidence interval [CI]: 7.64-19.48; p-value <0.001) and oral symptoms and functional limitation domains with the pooled means of 5.29 (CI: 2.83-7.74; p-value <0.001) and 3.04 (95% CI: 0.63-5.46; p-value = 0.001), respectively, increased significantly. However, the increase of emotional and social well-being domains with the pooled mean of 2.99 (CI: 0.02-5.97; p-value = 0.05) and 2.26 (CI:-0.35 to 4.86; p-value = 0.09), respectively, was not significant. The results revealed that in children with MIH, no significant relation was observed in the total score of P-CPQ with the pooled mean of 9.86 (CI: -0.76 to 20.48; p-value = 0.07) and all domains. Conclusions: MIH decreased OHRQoL in teenagers and significantly affected all domains except for emotional and social well-being. Parents/caregivers believed MIH did not affect OHRQoL.