Journal of applied physiology (Bethesda, Md. : 1985)HumansTreatment OutcomeTreatment Effect Heterogeneity
Concerns regarding the standard deviation of individual responses for assessing treatment response heterogeneity.
Aaron R Caldwell, David B Allison, Andrew W Brown, Gary L Gadbury, Thirupathi Reddy Mokalla, R Drew Sayer, Andrew D Vigotsky
Published: 202510.1152/japplphysiol.00485.2025
Abstract
The estimation of treatment response heterogeneity (TRH) is increasingly important as medicine moves toward personalized approaches. Although various statistical methods have been proposed to quantify TRH in parallel-group trials, the standard deviat…
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