American journal of physiology. Regulatory, integrative and comparative physiologyAnimalsMaleReceptorsG-Protein-CoupledCyclic AMP-Dependent Protein Kinases
The lactate-GPR81-PKA axis regulates exercise-induced central fatigue in male mice.
Junxia Li, Miaomiao Tan, Zegang Hu, Shuhong Zhou, Zhengbi Liu, Chunxiang Wang, Ping Li, Fabo Shan
Published: 202610.1152/ajpregu.00103.2025
Abstract
Exercise-induced fatigue is regulated by central nervous system (CNS)-derived factors, including neurotransmitters and metabolic signals; however, the underlying mechanisms remain incompletely understood. This study aimed to test whether lactate acti…
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