American journal of physiology. Heart and circulatory physiology
Eplerenone lowers maternal blood pressure in a model of leptin-induced preeclampsia, but decreases fetal growth when administered mid-, but not late-, gestation.
Elisabeth Mellott, Desmond Moronge, Gibson Cooper, Kristin Backer, Gabrielle Connor, Mona Elgazzaz, Safia Ogbi, Jessica L Faulkner
Published: 202610.1152/ajpheart.00522.2025
Abstract
Preeclampsia induces adverse cardiovascular outcomes for both mother and offspring. We established a novel leptin-induced mouse model of preeclampsia that induces hypertension, endothelial dysfunction, and fetal growth restriction, which are collecti…
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